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Recent Advances in Chest Medicine |

Coagulopathy in Critically Ill Patients: Part 1: Platelet Disorders

Todd W. Rice, MD, MSc; Arthur P. Wheeler, MD, FCCP
Author and Funding Information

Affiliations: From the Medical Intensive Care Unit (Drs. Rice and Wheeler), and the Division of Allergy, Pulmonary, and Critical Care Medicine (Dr. Wheeler), Vanderbilt University Medical Center, Nashville, TN.

Correspondence to: Arthur Wheeler, MD, FCCP, T-1210 MCN, Vanderbilt Medical Center, Nashville, TN 37232-2650; e-mail: art.wheeler@vanderbilt.edu


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2009 American College of Chest Physicians


Chest. 2009;136(6):1622-1630. doi:10.1378/chest.08-2534
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Abnormalities of platelet number and function are the most common coagulation disorders seen among ICU patients. This article reviews the most frequent causes of thrombocytopenia by providing an overview of the following most common mechanisms: impaired production; sequestration; dilution; and destruction. Guidelines for treating thrombocytopenia and platelet dysfunction are also provided.


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