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Original Research: LUNG CANCER |

5-Year Lung Cancer Screening Experience: Growth Curves of 18 Lung Cancers Compared to Histologic Type, CT Attenuation, Stage, Survival, and Size

Rebecca M. Lindell, MD; Thomas E. Hartman, MD; Stephen J. Swensen, MD; James R. Jett, MD, FCCP; David E. Midthun, MD, FCCP; Jayawant N. Mandrekar, PhD
Author and Funding Information

Affiliations: From the Departments of Radiology (Drs. Lindell, Hartman, and Swensen), Pulmonary and Critical Care Medicine (Drs. Jett and Midthun), and Biostatistics (Dr. Mandrekar), Mayo Clinic, Rochester, MN.

Correspondence to: Rebecca M. Lindell, MD, Mayo Clinic, Department of Radiology, 200 1st St SW, Rochester, MN 55905; e-mail: lindell.rebecca@mayo.edu


Funding/Support: This research was supported by National Cancer Institute grant RO1CA79935-04.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2009 American College of Chest Physicians


Chest. 2009;136(6):1586-1595. doi:10.1378/chest.09-0915
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Background:  Although no study has prospectively documented the rate at which lung cancers grow, many have assumed exponential growth. The purpose of this study was to document the growth of lung cancers detected in high-risk participants receiving annual screening chest CT scans.

Methods:  Eighteen lung cancers were evaluated by at least four serial CT scans (4 men, 14 women; age range, 53 to 79 years; mean age, 66 years). CT scans were retrospectively reviewed for appearance, size, and volume (volume [v] = π/6[ab2]). Growth curves (x = time [in days]; y = volume [cubic millimeters]) were plotted and subcategorized by histology, CT scan attenuation, stage, survival, and initial size.

Results:  Inclusion criteria favored smaller, less aggressive cancers. Growth curves varied, even when subcategorized by histology, CT scan attenuation, stage, survival, or initial size. Cancers associated with higher stages, mortality, or recurrence showed fairly steady growth or accelerated growth compared with earlier growth, although these growth patterns also were seen in lesser-stage lung cancers. Most lung cancers enlarged at fairly steady increments, but several demonstrated fairly flat growth curves, and others demonstrated periods of accelerated growth.

Conclusions:  This study is the first to plot individual lung cancer growth curves. Although parameters favored smaller, less aggressive cancers in women, it showed that lung cancers are not limited to exponential growth. Tumor size at one point or growth between two points did not appear to predict future growth. Studies and equations assuming exponential growth may potentially misrepresent an indeterminate nodule or the aggressiveness of a lung cancer.

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