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Original Research: 75 Seminal Studies, 1935–2009 |

Introduction: Lung Cancer

Loren J. Harris, MD, FCCP
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Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


Copyright © 2009 American College of Chest Physicians


Chest. 2009;136(5_suppl):e25. doi:10.1378/chest.09-2259
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Lung cancer is the leading cause of cancer-related mortality in the United States, with > 175,000 new cases expected this year—most victims will eventually succumb to the disease.1 Indeed, non-small cell lung cancer is the leading cause of cancer-related deaths worldwide and remains a pandemic.2 As the diagnosis and treatment of new cases of lung cancer became more frequent in the 1930s and beyond, the need to predict the response to treatments and survival became evident, and, thus, efforts to develop a staging systems intensified. The TNM system, as originally proposed by Denoix,3 was designed to “provide a consistent, reproducible, description for the anatomic extent of disease in cancer patients at a specific time in the life history of the cancer.” The landmark article by C.F. Mountain4 was a significant step toward this goal.

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lung cancer

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    Print ISSN: 0012-3692
    Online ISSN: 1931-3543