0
Original Research: 75 Seminal Studies, 1935–2009 |

Introduction: Tuberculosis

Glenn S. Tillotson, PhD, FCCP
Author and Funding Information

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


Copyright © 2009 American College of Chest Physicians


Chest. 2009;136(5_suppl):e19. doi:10.1378/chest.09-2263
Text Size: A A A
Published online

Extract

Diseases of the Chest “cut its teeth” in the emerging field of TB in the 1930s, when the complex milieu included poor social conditions, improved understanding of epidemiology, changing dietary habits, and, later, the advent of chemotherapeutic agents, such as sulfa drugs and other more toxic agents. Diseases of the Chest embraced this theme from many different aspects and provided a wonderful vehicle for practitioners to improve the management of this complex disease. Several papers described new individual agents and their activity against Mycobacterium tuberculosis; however, it was the work by Frederic J. Hughes and colleagues1 in 1952 that raised the possible use of a combined intermittent regimen in the treatment of nonmiliary pulmonary TB. The appreciation that optimal therapy for TB would require a regimen not previously considered was beginning to emerge in the late 1940s, with this Colorado-based group conducting an intriguing comparison of daily vs every-3-days combination of two agents, streptomycin and para-aminosalicyclic acid (PAS). The balance of eradication of the tubercle bacillus and the acknowledged toxicity profile of these agents was clearly crucial. Following a well-controlled, although numerically small study, these researchers established that intermittent streptomycin with daily PAS provided good clinical responses and reduced development of drug resistance.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543