As the ACCP celebrates 75 years of inspiration, so does CHEST. To honor the occasion, this CHEST 75th Commemorative Edition highlights 75 seminal studies that have been published in the journal since the first issue in March 1935. I would like to thank Loren J. Harris, MD, FCCP, and Glenn S. Tillotson, PhD, FCCP, for spearheading this project. As members of the ACCP Marketing Committee, Drs. Harris and Tillotson conceived the idea and drove it forward. They tirelessly reviewed > 36,000 articles from all past issues and evaluated each study's influence to select the 75 seminal studies. The top 75 are listed in a special online collection at www.chestjournal.org/content/136/5_suppl. From the top 75 articles, Drs. Harris and Tillotson further narrowed their selection to the 12 most important studies, which are reprinted in this commemorative edition. The citations for the remaining 63 articles are listed at the end. Drs. Harris and Tillotson have made excellent selections, and I encourage you to read their “Introduction to 75 Years of Publishing CHEST” to understand and appreciate their process.