A 51-year-old woman with a medical history of hypertension, hypercholesterolemia, ischemic heart disease, and depression presented to our cough clinic with a 12-month history of dry cough. One year previous, she had received a diagnosis of normal-tension glaucoma. The patient was receiving therapy with nifedipine, aspirin, propranolol, atorvastatin, co-amilofruse, fluoxetine, dorzolamide, and latanoprost eye drops. Symptoms suggested the possibility of reflux, including heartburn and cough on phonation. The patient mentioned that the onset of cough was related to the commencement of therapy with topical latanoprost. She denied any wheeze, dyspnea, weight loss, hemoptysis, or chest pain. She was an ex-smoker, with a 20-pack-year history of smoking. She had no history of respiratory problems, and the family history was unremarkable. On examination, there was no evidence of nasal obstruction. The findings of a systemic examination, including the respiratory system, were unremarkable. A chest radiograph showed left basal pleural thickening, which was longstanding. Spirometry findings were normal.