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Airway Involvement in Sarcoidosis

Vlassis S. Polychronopoulos, MD, FCCP; Udaya B. S. Prakash, MD, FCCP
Author and Funding Information

Affiliations: From the Third Pulmonary Department (Dr. Polychronopoulos), Sismanoglion General Hospital, Athens, Greece; and Pulmonary and Critical Care Medicine (Dr. Prakash), Mayo Clinic College of Medicine, Rochester, MN.

Correspondence to: Vlassis S. Polychronopoulos, MD, FCCP, Director, Third Chest Department, Sismanoglion Hospital-Athens, 14, Achilleos St, Athens 15342 Greece; e-mail: vlasispo@hotmail.com


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2009 American College of Chest Physicians


Chest. 2009;136(5):1371-1380. doi:10.1378/chest.08-2569
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Sarcoidosis is a common disease and affects the respiratory system in > 90% of cases, most commonly the intrathoracic lymph nodes and the respiratory parenchyma. Less commonly, the airways are involved, and the disease is manifested as mucosal erythema, edema, granularity and cobblestoning, plaques, nodules, and bronchial stenosis, airway distortion, traction bronchiectasis, and bronchiolitis. Airway involvement may lead to airflow limitation. Involvement of oral, nasal, and pharyngeal mucosa may cause hoarseness, dysphagia, laryngeal paralysis, and upper airway obstruction. Airway symptoms are important indicators of airway involvement in sarcoidosis. Pulmonary function testing, radiologic imaging, and bronchoscopy occupy a significant role in the diagnosis and management of airway involvement in patients with sarcoidosis.

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