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Original Research: PULMONARY EMBOLISM |

Recent Trends in Clinical Outcomes and Resource Utilization for Pulmonary Embolism in the United States: Findings From the Nationwide Inpatient Sample

Brian Park, MD; Louis Messina, MD; Phong Dargon, MD; Wei Huang, MS; Rocco Ciocca, MD; Frederick A. Anderson, PhD
Author and Funding Information

Affiliations: From the Department of Surgery (Drs. Park, Messina, and Dargon), Division of Vascular Surgery, and Center for Outcomes Research (Ms. Huang and Dr. Anderson), University of Massachusetts Medical School, Worcester, MA; and the Department of Surgery (Dr. Ciocca), Division of Vascular Surgery, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA.

Correspondence to: Frederick A. Anderson, PhD, University of Massachusetts Medical School, Center for Outcomes Research, 365 Plantation St, Suite 185, Worcester, MA 01605; e-mail: fred.anderson@umassmed.edu


This work was presented at the annual meeting of the Society for Clinical Vascular Surgery, Las Vegas, NV, March 5–8, 2008.

This work was funded by the Center for Outcomes Research, Department of Surgery, University of Massachusetts Medical School, Worcester, MA. No commercial sponsorship or other external financial support was used in the conduct of this work.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2009 American College of Chest Physicians


Chest. 2009;136(4):983-990. doi:10.1378/chest.08-2258
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Background:  Pulmonary embolism (PE) has been cited as the most common preventable cause of death in hospitalized patients. The objectives of this study were to determine recent trends in clinical outcomes and resource utilization for hospitalized patients with a clinically recognized episode of acute PE.

Methods:  Patients with primary or secondary PE who had been discharged from US acute care hospitals were identified from the Nationwide Inpatient Sample during the 8-year period between 1998 and 2005. The major clinical outcomes assessed included hospital mortality and length of hospitalization. To assess resource utilization for the treatment of PE, average hospital charges for these admissions were assessed, normalized to 2005 US dollars, and adjusted to reflect the US consumer price index.

Results:  Between 1998 and 2005, the number of patients with primary or secondary PE on discharge from the hospital increased from 126,546 to 229,637; hospital case fatality rates for these patients decreased from 12.3 to 8.2% (p < 0.001); length of hospital stay decreased from 9.4 days to 8.6 days (p < 0.001); and total hospital charges increased from $25,293 to $43,740 (p < 0.001).

Conclusions:  Between 1998 and 2005, significant improvements were observed in outcomes for patients hospitalized for clinically recognized PE, including decreases in mortality and length of hospital stay. Charges for this hospital care increased during this time period.

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