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Original Research: COUGH |

Associated Factors in Children With Chronic Cough

Vikram Khoshoo, MD, PhD; Dean Edell, MD, MPH, FCCP; Sopan Mohnot; Robert Haydel, Jr, MD; Emilio Saturno, MD; Aaron Kobernick, MD, MPH
Author and Funding Information

Affiliations: From the West Jefferson Medical Center (Drs. Khoshoo, Edell, Haydel, and Saturno), New Orleans, LA; Tulane University (Ms. Mohnot), New Orleans, LA; and Tulane University Medical Center (Dr. Kobernick), New Orleans, LA.

Correspondence to: Vikram Khoshoo, MD, PhD, Pediatric Specialty Center, West Jefferson Medical Center, 1111 Medical Center Blvd, South 650, Marrero, LA 70072; e-mail: vkhoshoo@sbcglobal.net


This article was presented in part at the Annual Conference of American College of Chest Physicians, Chicago, IL, October 24, 2007.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.xhtml).


© 2009 American College of Chest Physicians


Chest. 2009;136(3):811-815. doi:10.1378/chest.09-0649
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Background:  Children presenting with chronic cough are common to the primary care physicians, but data on the etiology are scant.

Methods:  We evaluated 40 children (age range, 5 to 12 years) with chronic cough (> 8 weeks duration) with no obvious cause who were referred by their primary care physicians. All patients underwent an extensive multispecialty workup that included pulmonary, GI, allergy, immunology, and otorhinolaryngology testing. Response to treatment was quantified pretreatment and 8 weeks after treatment by using a visual analog scale.

Results:  Positive diagnostic test results were noted for gastroesophageal reflux disease (27.5%), allergy (22.5%), asthma (12.5%), infection (5%), aspiration (2.5%), and multiple etiologies (20%). Appropriate treatment for these factors resulted in a significant improvement in cough.

Conclusion:  Reflux, allergy, and asthma accounted for > 80% of the likely etiologic factors of chronic cough in children and responded to a¡ppropriate treatment.


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