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Original Research: PULMONARY HYPERTENSION |

Incidence of Pleural Effusions in Idiopathic and Familial Pulmonary Arterial Hypertension Patients

Ke-jing Tang, MD, PhD; Ivan M. Robbins, MD; Richard W. Light, MD, FCCP
Author and Funding Information

Affiliations: From the Department of Pulmonary Medicine (Dr. Tang), The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China; and the Division of Allergy, Pulmonary, and Critical Care Medicine (Drs. Tang, Robbins, and Light), Vanderbilt University Medical Center, Nashville, TN.

Correspondence to: Ke-jing Tang, MD, PhD, The First Affiliated Hospital of Sun Yat-sen University, Department of Pulmonary Medicine, 58 ZhongShan Rd 2, Guangzhou, Guangdong 510080, People's Republic of China; e-mail: tangkejing@gmail.com


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2009 American College of Chest Physicians


Chest. 2009;136(3):688-693. doi:10.1378/chest.08-0659
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Background:  Pleural effusion occurs often in patients with left heart failure. There are no large-scale clinical studies investigating the incidence of pleural effusion in patients with right heart failure (RHF) alone.

Objectives:  To determine the incidence of pleural effusions in patients with idiopathic pulmonary arterial hypertension (IPAH) and familial pulmonary arterial hypertension (FPAH).

Methods:  Consecutive IPAH and FPAH patients who were treated at Vanderbilt University Medical Center were retrospectively studied. Pleural effusions were detected by chest radiograph, chest CT scan, ultrasound, or autopsy.

Results:  Thirty-one of 147 patients (21.1%) with IPAH (128 patients) or FPAH (19 patients) had pleural effusions. Ten patients had explanations for the pleural effusions other than RHF. Two patients had no obvious explanations. The remaining 19 patients had RHF. When compared with the patients without pleural effusions, the patients with pleural effusions due to RHF had significantly higher mean right atrial pressure (16.0 ± 6.8 vs 8.8 ± 5.5 mm Hg, respectively; p < 0.001). There was no significant difference in other hemodynamic parameters between the two patient groups. The majority of effusions due to RHF are trace to small (63.2%) and right sided (57.9%) or bilateral (26.3%). Of the 19 patients with pleural effusions due to RHF, 8 patients had ascites, and 1 patient had moderate pericardial effusion. Four of the five patients who underwent thoracentesis had transudates.

Conclusions:  Our study in IPAH and FPAH patients demonstrates that pleural effusions frequently occur in patients with isolated RHF.


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