0
Original Research: INTERVENTIONAL PULMONOLOGY |

Results of Long-term Follow-up of Photodynamic Therapy for Roentgenographically Occult Bronchogenic Squamous Cell Carcinoma

Chiaki Endo, MD, PhD; Akira Miyamoto, MD, PhD; Akira Sakurada, MD, PhD; Hirokazu Aikawa, MD, PhD; Motoyasu Sagawa, MD, PhD; Masamai Sato, MD, PhD; Yasuki Saito, MD, PhD; Takashi Kondo, MD, PhDFCCP
Author and Funding Information

From the Department of Thoracic Surgery (Drs. Endo, Sakurada, and Kondo), Institute of Development, Aging and Cancer, Tohoku University Hospital, Tohoku University, Sendai, Japan; the Department of Thoracic Surgery (Dr. Miyamoto), Aomori Prefectural Central Hospital, Aomori, Japan; the Department of Thoracic Surgery (Drs. Aikawa and Sagawa), Kanazawa Medical University, Uchinada, Japan; the Department of Thoracic Surgery (Dr. Sato), Miyagi Cancer Center, Natori, Japan; and the Department of Thoracic Surgery (Dr. Saito), Sendai Medical Center, Sendai, Japan.

Chiaki Endo, MD, PhD, Institute of Development, Aging and Cancer, Tohoku University, Department of Thoracic Surgery, 4-1 Seiryo-machi, Aoba-ku Sendai 980-8575, Japan; e-mail: endo@idac.tohoku.ac.jp


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2009 American College of Chest Physicians


Chest. 2009;136(2):369-375. doi:10.1378/chest.08-2237
Text Size: A A A
Published online

Background:  Photodynamic therapy (PDT) is considered a useful and minimally invasive modality for treating centrally located early lung cancer. To date, there has been limited information on the long-term outcome of patients treated with PDT, especially those who are medically operable.

Methods:  Beginning in 1994, patients with roentgenographically occult bronchogenic squamous cell carcinoma (ROSCC) who met our criteria underwent PDT at Tohoku University Hospital and were followed up through 2006. Our criteria were as follows: (1) ROSCC without distant metastasis; (2) medically operable by means of lobectomy or further resection; (3) longitudinal tumor length of ≤ 10 mm; and (4) superficial bronchoscopic tumor findings.

Results:  A total of 48 patients with ROSCC underwent PDT. The complete response (CR) rate was 94% (45 of 48 of patients). Nine patients (20%) had local recurrence after CR. A total of 11 deaths was observed, with 6 resulting from multiple primary lung cancer and only 1 from the original ROSCC. The 5-year and 10-year overall survival rates for all 48 patients were 81% and 71%, respectively. The Cox proportional hazard model showed that only metachronous multiple primary lung cancer was an independent poor prognostic factor.

Conclusions:  PDT is thought to be a first-line modality for patients who have ROSCC with a tumor length of ≤ 10 mm, even if the tumor is medically operable. Most local recurrence can be cured by active therapy such as surgery, radiotherapy, or PDT. Multiple primary lung cancer subsequent to PDT is an important issue from the viewpoint of survival.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
Guidelines for topical photodynamic therapy: update.
British Association of Dermatologists | 7/17/2009
Practice parameters for anal squamous neoplasms.
American Society of Colon and Rectal Surgeons | 9/26/2008
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543