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Recombinant Activated Factor VII for Massive Hemoptysis in Patients With Cystic Fibrosis

Edmund M. T. Lau, MD; Veronica Yozghatlian, MD; Chris Kosky, MD; Carmel Moriarty, RN; Ruth Dentice, BAppSc; Richard Waugh, MD; Paul J. Torzillo, MD; Peter T. Bye, MD, PhD
Author and Funding Information

From the Departments of Respiratory and Sleep Medicine (Drs. Lau, Yozghatlian, Kosky, Torzillo, and Bye, Ms. Dentice, and Ms. Moriarty) and Radiology (Dr. Waugh), Royal Prince Alfred Hospital, Sydney, NSW, Australia; and Woolcock Institute of Medical Research and University of Sydney (Dr. Bye), Sydney, NSW, Australia.

Correspondence to: Peter T. Bye, MD, PhD, Director of Cystic Fibrosis Service, Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia; e-mail: peterb@med.usyd.edu.au


The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2009 American College of Chest Physicians


Chest. 2009;136(1):277-281. doi:10.1378/chest.08-2948
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Massive hemoptysis is a common complication in patients with cystic fibrosis (CF) and is associated with significant morbidity and mortality. Conventional treatment with antibiotic therapy and early bronchial artery embolization (BAE) is usually successful in achieving hemostasis in the majority of patients. Recombinant activated factor VII (rFVIIa), originally developed for use in patients with hemophilia, has emerged as a general hemostatic agent that is potentially useful in the management of many life-threatening bleeding conditions. In this article, we present four patients with CF lung disease and massive hemoptysis who were treated successfully with rFVIIa. We suggest that in patients with CF who present with massive hemoptysis, the use of rFVIIa can be considered in patients with refractory hemoptysis despite conventional therapy or as a temporizing therapy when BAE is not immediately available.

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