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Allergic Bronchopulmonary Aspergillosis After Infliximab Therapy for Sarcoidosis: A Potential Mechanism Related to T-Helper Cytokine Balance

Marc A. Judson, MD, FCCP
Author and Funding Information

From Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC.

Correspondence to: Marc A. Judson, MD, Division of Pulmonary and Critical Care Medicine CSB-812, 96 Jonathan Lucas St, Charleston, SC 29425; e-mail: judsonma@musc.edu


Dr. Judson has received previous grants from Centocor.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2009 American College of Chest Physicians


Chest. 2009;135(5):1358-1359. doi:10.1378/chest.08-2106
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We report a case of allergic bronchopulmonary aspergillosis (ABPA) that occurred in a man receiving infliximab for systemic sarcoidosis. His symptoms associated with ABPA were temporally related to his infliximab infusions. We suspect that infliximab disrupted the T-helper (Th) type 1-Th2 lymphocyte balance such that Th2 cytokines were left relatively unopposed, promoting the development of ABPA.


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