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Original Research: PULMONARY HYPERTENSION |

Bosentan Decreases Pulmonary Vascular Resistance and Improves Exercise Capacity in Acute Hypoxia

Vitalie Faoro, MSc, PhD; Saskia Boldingh, MSc; Mickael Moreels, MD; Sarah Martinez, MSc; Michel Lamotte, MSc; Philippe Unger, MD, PhD; Serge Brimioulle, MD, PhD; Sandrine Huez, MD, PhD; Robert Naeije, MD, PhD
Author and Funding Information

*From the Department of Physiology (Drs. Faoro and Naeije, and Ms. Martinez), Faculty of Medicine, Free University of Brussels, Belgium; VU University Medical Center (Ms. Boldingh), Amsterdam, the Netherlands; and the Departments of Cardiology (Drs. Moreels, Unger, and Huez, and Mr. Lamotte), and Intensive Care (Dr. Brimioulle), Erasme University Hospital, Brussels, Belgium.

Correspondence to: Robert Naeije, MD, PhD, Department of Physiology, Erasme Campus CP 604, 808 Lennik Rd, B-1070 Brussels, Belgium; e-mail: rnaeije@ulb.ac.be


Supported by the Foundation of Cardiac Surgery and by the Fonds de la Recherche Scientifique Médicale (grant No. 3.4551.05), Belgium. Dr. Huez was a fellow of the Fonds National de la Recherche Scientifique, Brussels, Belgium.

The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2009 American College of Chest Physicians


Chest. 2009;135(5):1215-1222. doi:10.1378/chest.08-2222
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Background:  Altitude exposure is associated with mild pulmonary hypertension and decreased exercise capacity. We tested the hypothesis that pulmonary vascular resistance (PVR) contributes to decreased exercise capacity in hypoxic healthy subjects.

Methods:  An incremental cycle ergometer cardiopulmonary exercise test and echocardiographic estimation of pulmonary artery pressure (Ppa) and cardiac output to calculate total PVR were performed in 11 healthy volunteers in normoxia and after 1 h of hypoxic breathing (12% O2). The measurements were performed in a random order at 1-week intervals after the receiving either a placebo or bosentan, following a double-blind randomized crossover design. Bosentan was administered twice a day for 3 days, 62.5 mg on the first day and 125 mg on the next 2 days.

Results:  Hypoxic breathing decreased the mean (± SE) pulse oximetric saturation (Spo2) from 99 ± 1% to 3 ± 1% and increased the mean PVR from 5.6 ± 0.3 to 7.2 ± 0.5 mm Hg/L/min/m2, together with a decrease in mean maximum O2 uptake (V̇o2max) from 47 ± 2 to 35 ± 2 mL/kg/min. Bosentan had no effect on normoxic measurements and did not affect hypoxic Spo2, but decreased PVR to 5.6 ± 0.3 mm Hg/L/min/m2 (p < 0.01) and increased V̇o2max to 39 ± 2 mL/kg/min (p < 0.01) in hypoxia. Bosentan therapy, on average, restored 30% of the hypoxia-induced decrease in V̇o2max. Bosentan-induced changes in Ppa and V̇o2max were correlated (p = 0.01).

Conclusions:  We conclude that hypoxic pulmonary hypertension partially limits exercise capacity in healthy subjects, and that bosentan therapy can prevent it.

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