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Sustained Improvement With Iloprost in a COPD Patient With Severe Pulmonary Hypertension

Matthew J. Hegewald, MD, FCCP; C. Gregory Elliott, MD, FCCP
Author and Funding Information

*From the Division of Pulmonary and Critical Care Medicine Intermountain Medical Center, University of Utah School of Medicine, Salt Lake City, UT.

Correspondence to: Matthew Hegewald, MD, FCCP, Pulmonary Division, Intermountain Medical Center, PO Box 577000, Murray, UT 84157-7000; e-mail: matt.hegewald@imail.org


Dr. Hegewald has received research funding from Actelion. Dr. Elliott has provided consultant services for Actelion and has received research funding from Actelion.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).


Chest. 2009;135(2):536-537. doi:10.1378/chest.08-1515
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Pulmonary hypertension is an important complication of COPD. A small subset of patients with COPD have severe pulmonary hypertension (PH) that is out of proportion to the mild increase in pulmonary arterial pressure observed commonly. Severe PH associated with COPD is associated with increased morbidity and mortality. Treatment options in this group of patients are limited with no conclusive evidence of benefit when drugs approved for treatment of pulmonary arterial hypertension are used. We describe a patient with severe PH associated with COPD who improved clinically and hemodynamically when treated with inhaled iloprost. The improvement was sustained for 2 years. Severe PH in patients with COPD needs to be recognized and novel treatment approaches considered.


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