Adipose tissue is not simply a passive storage organ but is a complex metabolically active tissue, with important endocrine and immune functions.11 Adipose tissue produces a number of mediators, termed adipokines, which have significant metabolic effects. One of these adipokines, adiponectin, is actually decreased in the obese. Adiponectin has antiinflammatory properties: low adiponectin levels have been associated with accelerated atherosclerosis and increased metabolic stress.12 Low adiponectin levels have also been associated with asthma in population studies.13,14 The relevance of adiponectin to asthma may not be immediately obvious, but Shore et al15 have shown that adiponectin infusion can decrease airway hyperreactivity in a mouse model of allergic asthma. Not only that, but allergen challenge decreases adiponectin levels in adipose tissue and serum15; therefore, in mice, low adiponectin may both contribute to and be a result of allergic asthma. This has not previously been studied in humans but is an important issue. If low adiponectin levels are the result of allergic asthma, this represents an interesting link between the lung and adipose tissue; but if low adiponectin levels could be involved in the pathogenesis of asthma, this suggests potential opportunity for intervention in obese asthmatics.