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Paul Karanicolas, MD; Gordon Guyatt, MD, MSc, FCCP; Regina Kunz, MD, PhD
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Affiliations: Department of Clinical Epidemiology and Biostatistics,  Department of Medicine McMaster University Medical Center Hamilton, ON, Canada,  Basler Institute for Clinical Epidemiology University Hospital Basel Basel, Switzerland

Correspondence to: Gordon Guyatt, MD, MSc, FCCP, Department of Medicine, McMaster University Medical Center, 1200 Main St W, Room 2C12, Hamilton, ON, Canada L8N 3Z5; e-mail: guyatt@mcmaster.ca

The authors have no conflicts of interest to disclose.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).


The authors have no conflicts of interest to disclose.

The authors have no conflicts of interest to disclose.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).


Chest. 2009;135(1):245-246. doi:10.1378/chest.08-2198
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To the Editor:

The comments of Drs. Sestini and Irvings reinforce our understanding that the views of science of Dr. Tobin are very consistent with current evidence-based medicine thinking and writing. We agree that Dr. Tobin's analysis mandates thoughtful reflection, and such reflection may further enhance the sophistication of evidence-based decision making.


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