PURPOSE: To characterize gender differences in non small cell lung cancer (NSCLC
METHODS: Retrospectively collected data on 495 patients undergoing lung resection for NSCLC between 1985 and 2009 in a single unit were analysed.
RESULTS: 354 (72%) patients were male (mean age 61,4± 10 years) and 138 were female (mean age 60,2 ± 11,4 years) (P=0,290). Compared with men, women were more likely to be nonsmokers (23,7 vs 8,8%, p = <0 ,0001) and have a solitary pulmonary nodule (45,2 vs 33,0%, p = 0,017) and a clinical suspicion of N2 (4,5% vs 10,6%, p =0,033) . There were no differences in other clinical variables, for example: proportion of asymptomatic patients, large airway involvement, central location, complication rate, operative mortality, etc. During surgery requirement of a pneumonectomy was not different, neither the proportion of a patients with a resection considered curative or with a pathological N2. Adenocarcinoma was the most prevalent histology in both groups and the proportion of patients with lymphatic emboli or vascular emboli was not different. Overall survival was not different (p = 0,133). If only patients in Stage I was considered there were not differences in 5-year survival (p= 0,357). If first half of our series of 26 years is compared, the percentage of women increased from the 20 to 32% (p = 0,05). Nevertheless, the percentage of smokers (89,1% versus 85,1%) and the percentage of women smokers(66,7 versus 72,9) in both periods were not different.
CONCLUSIONS: In our group of patients women were non smokers but there were no differences in the prevalence of adenocarcinoma or in the 5-year survival after surgical resection. The increase of the prevalence of NSCLC in the women seems related to the increase of tobacco addiction and not in the increase of the NSCLC in nonsmokers
CLINICAL IMPLICATIONS: Regional differences related to genetic or environmental factors can explain the differences between series of different regions from the world
DISCLOSURE: The following authors have nothing to disclose: Ileana Palma, Silvia Quadrelli, Lorena Delisio, Sebastian Lamot, Marcos Hernandez, Gustavo Lyons, Domingo Chimondeguy
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