PURPOSE: Several reports have demonstrated reduced regional cerebral blood flow during wakefulness in obstructive sleep apnea (OSAS). Our objective was to investigate the change in regional cerebral blood flow in OSAS after treatment with continuous positive airway pressure (CPAP).
METHODS: Eight moderate to severe OSAS patients aged 37 to 61 and six control healthy subjects matched for age were enrolled in the study. All patients underwent overnight polysomnography and their mean apnea-hypopnea index was 52.9±17.3 per hour (range 20-68.2). Technetium-99m ethyl cysteine (Tc-ECD) single photon emission computed tomography (SPECT) during the day was used to assess regional cerebral blood flow (rCBF) before and after treatment of CPAP for more than 3 months. Six control subjects matched for age also underwent SPECT studies.
RESULTS: Compared to control subjects, OSAS patients before CPAP showed significant reduction of rCBF in frontal and temporal area.
CONCLUSIONS: We would further present the change in cerebral blood flow after treatment with CPAP.
CLINICAL IMPLICATIONS: Our study may suggest that OSA patients improve the daytime regional cerebral blood flow after treating with CPAP.
DISCLOSURE: The following authors have nothing to disclose: Satomi Shiota, Chie Usui, Hidenori Takekawa, Yasuko Yoshioka, Tastuo Koga, Yuichi Inoue, Kazuhisa Takahashi
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