Slide Presentations: Wednesday, October 26, 2011 |

Effect of Continuous Positive Airway Pressure on Regional Cerebral Blood Flow During Wakefulness in Obstructive Sleep Apnea FREE TO VIEW

Satomi Shiota, PhD; Chie Usui, PhD; Hidenori Takekawa, MD; Yasuko Yoshioka, PhD; Tastuo Koga, MD; Yuichi Inoue, PhD; Kazuhisa Takahashi, PhD
Chest. 2011;140(4_MeetingAbstracts):1069A. doi:10.1378/chest.1118652
Text Size: A A A
Published online


PURPOSE: Several reports have demonstrated reduced regional cerebral blood flow during wakefulness in obstructive sleep apnea (OSAS). Our objective was to investigate the change in regional cerebral blood flow in OSAS after treatment with continuous positive airway pressure (CPAP).

METHODS: Eight moderate to severe OSAS patients aged 37 to 61 and six control healthy subjects matched for age were enrolled in the study. All patients underwent overnight polysomnography and their mean apnea-hypopnea index was 52.9±17.3 per hour (range 20-68.2). Technetium-99m ethyl cysteine (Tc-ECD) single photon emission computed tomography (SPECT) during the day was used to assess regional cerebral blood flow (rCBF) before and after treatment of CPAP for more than 3 months. Six control subjects matched for age also underwent SPECT studies.

RESULTS: Compared to control subjects, OSAS patients before CPAP showed significant reduction of rCBF in frontal and temporal area.

CONCLUSIONS: We would further present the change in cerebral blood flow after treatment with CPAP.

CLINICAL IMPLICATIONS: Our study may suggest that OSA patients improve the daytime regional cerebral blood flow after treating with CPAP.

DISCLOSURE: The following authors have nothing to disclose: Satomi Shiota, Chie Usui, Hidenori Takekawa, Yasuko Yoshioka, Tastuo Koga, Yuichi Inoue, Kazuhisa Takahashi

No Product/Research Disclosure Information

01:45 PM - 03:00 PM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543