PURPOSE: Improvement of health-related quality of life (HRQL) is one of the main goals in treating chronic obstructive pulmonary disease (COPD). Impaired HRQL in COPD is associated with increased morbidity and mortality, hospitalizations and burden on the health care system. The Clinical COPD Questionnaire (CCQ) is a validated, reliable, short questionnaire for the evaluation of disease specific HRQL in patients with COPD. This study investigated factors that might affect CCQ outcome in COPD in primary care setting.
METHODS: In a population of COPD patients in primary care, multivariate regression analyses was used to assess associations between CCQ scores and FEV1%predicted, age, sex, body mass index, current smoking, depression and heart failure. Subgroup analyses were done to determine the clinical relevance of factors which were significantly associated with CCQ-scores.
RESULTS: Data of 341 patients (mean age 68.1±10.3, COPD GOLD class I-III) were used for analyses. Together, heart failure and depression explained 23% of the variance in CCQ total score (p<0.001). Heart failure was most strongly associated with CCQ functional score (27% explained variance, p<0.001), whereas depression was most strongly associated with CCQ mental score (22% explained variance, p<0.001). In both groups with and without heart failure and with and without depression, differences in mean CCQ-scores in these domains were larger than the minimal clinically important difference of 0.4 points (both p<0.001).
CONCLUSIONS: Although the CCQ is a HRQL questionnaire for COPD specifically, its scores are negatively associated with heart failure and depression in patients from a primary care setting.
CLINICAL IMPLICATIONS: -
DISCLOSURE: The following authors have nothing to disclose: Manon Urff, Jan-Willem van den Berg, Steven Uil, Roger Damoiseaux
No Product/Research Disclosure Information