PURPOSE: To correlate serum CRP levels with outcome in COPD and Tuberculosis patient.
METHODS: METHODS:: Patient with No exacerbation in last 2 months were included for the study. Parameters correlated were- Age, Grade of Dyspnea, FEV1. Inclusion -Smoker less than 20 packs years per day. Post bronchodilator increase in FEV1 less than 12%.Patients were clinically stable (no exacerbation for 2 months).Exclusion - Asthma and/or FEV1 increased more than 12% or 200 mL after bronchodilation The following variables, which are known to predict outcome in COPD, were evaluated: age, dyspnoea, degree of airflow obstruction, via FEV1. Level of Dyspnoea was graded according to New York Heart and Lung Classification. Blood samples for CRP measurement were taken after 4 h of fasting, at the same time of the day 08:00 h. Statistical analysis was done Pearson’s correlations with CRP and Spearman’s Correlation. We also documented 60 Sputum Positive pulmonary tubercular cases,45 male and 15 female respectively , we evaluated all the patients in follow-up after two months of anti tubercular therapy,DOTS.
RESULTS: Values of CRP increases inversely with FEV1,-.736, P<0.001. CRP is negatively associated with dyspnoea, CRP increases inversely with increase in level of dyspnoea.734, P<0.001. In tubercular patients serum CRP was significantly higher in smear-positive group as compared with the smear-negative group,Healthy control and follow-up patients. The values being 18.83±7.87, 4.04±3.85 and 4.60±3.34 mg/lit respectively-P < 0.0001. In smear-positive patients, CRP levels were highest in AFB3+ patients 20.21±9.79 as compared with the AFB2+ patients 17.85±7.53, AFB1+ patients 17.62±3.89 and AFB scanty patients 15.92±1.66 respectively, statistically, the difference was found to be significant P < 0.0001. It was found that higher CRP level have late AFB smear conversion.
CONCLUSIONS: Serum C-Reactive Protein can predict outcome in COPD and Tuberculosis patients
CLINICAL IMPLICATIONS: COPD Patients with high CRP levels should be managed aggressively and Tuberculosis patients with high CRP are increase chances of Drug Resistance Tuberculosis.
DISCLOSURE: The following authors have nothing to disclose: Nazish Fatima, Mohammad Shameem, Abida Malik, Indu Shukla, Asrar Ahmad, Jamal Akhtar
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