PURPOSE: To assess if the concentration of SCF and its soluble receptor c-kit in peripheral blood is increased in patients with asthma and if it correlates with disease severity and asthma phenotype.
METHODS: The study involved 51 patients with bronchial asthma, well characterized with respect to severity and 7 healthy controls. SCF assessed in 29 patients with bronchial asthma (severe - non-severe), and soluble c-kit was evaluated in 22 asthmatic patients also according to severity. Concentration of SCF and sc-kit in the patients' serum were measured by ELISA method.
RESULTS: Mean serum SCF level in the group of asthmatics (n= 29) was significantly higher as compared to healthy controls. The level of SCF was higher in patients with severe asthma as compared to patients with non-severe asthma. The mean sc-kit serum level (n= 22) did not differ between asthmatic patients and healthy controls; however the level of sc-kit in non-severe asthmatics was significantly higher as compared to patients with severe asthma and healthy controls. The level of sc-kit correlated positively with FEV1% predicted value.
CONCLUSIONS: Serum levels of SCF and its soluble receptor c-kit increased according to asthma severity and this indicates the role for these molecules in asthmatic inflammation.
CLINICAL IMPLICATIONS: N/A
DISCLOSURE: The following authors have nothing to disclose: Tarek Safwat, Neveen Abdel Fattah, Sandy Abu-Hussein
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