Poster Presentations: Wednesday, October 26, 2011 |

Evaluation of the St. George Respiratory Questionnaire to Measure Health-Related Quality of Life in Patients With Treated Pulmonary Tuberculosis FREE TO VIEW

Mikhail Chushkin, MD; Sergey Yartsev, MD; Dmitriy Zhutikov, MD; Elena Bogorodskaya, MD; Sergey Smerdin, MD
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Research Institute of Phthisiopulmonology, I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

Chest. 2011;140(4_MeetingAbstracts):768A. doi:10.1378/chest.1112278
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PURPOSE: Tuberculosis remains a public health problem with significant impacts on morbidity and mortality. With effective treatment, the focus of tuberculosis management has shifted from the prevention of mortality to the avoidance of morbidity. Pulmonary tuberculosis can result in anatomic and functional changes. The aim of this work was to assess the validity and reliability of the the St. George respiratory questionnaire (SGRQ) in patients with a history of tuberculosis and then to examine the impact of the treated pulmonary tuberculosis on quality of life (QoL).

METHODS: QoL was studied in 295 persons at the age of 20-82 who were observed at the local dispensary. SGRQ was used for assessment of QoL.

RESULTS: The SGRQ scores correlated with forced expiratory volume in 1 second in predicted value (FEV1%); Pearson correlation coefficient ranged from -0,51 to -0,55 (all p<0.01). Test-retest correlation ranged from 0,94 to 0,99 (all p<0.01). Cronbach's Alpha was 0,89 (p<0.01). All the SGRQ components for participants with treated pulmonary tuberculosis were worse in comparison with healthy subjects. In 295 persons Symptoms score was 27,5±24,6%; Activity score was 28,9±23,4%; Impact score was 17,1±19,5%; and Total score was 22,2±20,1%. All the SGRQ components for patients with pulmonary impairment (FEV1<80% predicted) were worse than in patients with normal spirometry results (all p<0.01).

CONCLUSIONS: The SGRQ scores were valid and reliable. Quality of life in patients treated for pulmonary tuberculosis remained lowered even after treatment was completed. The main factor influencing quality of life was impaired pulmonary function.

CLINICAL IMPLICATIONS: This supports more aggressive treatment of pulmonary tuberculosis to prevent long-term health loss.

DISCLOSURE: The following authors have nothing to disclose: Mikhail Chushkin, Sergey Yartsev, Dmitriy Zhutikov, Elena Bogorodskaya, Sergey Smerdin

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