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Original Research: PULMONARY FUNCTION TESTING |

Grading the Severity of Obstruction in Mixed Obstructive-Restrictive Lung DiseaseGrading Obstruction in Mixed Lung Disease

Zechariah S. Gardner, MD; Gregg L. Ruppel, MEd, RRT, RPFT; David A. Kaminsky, MD, FCCP
Author and Funding Information

From the Department of Medicine (Dr Gardner), and Division of Pulmonary and Critical Care Medicine (Dr Kaminsky), University of Vermont College of Medicine, Burlington, VT; and St. Louis University Hospital (Mr Ruppel), St. Louis, MO.

Correspondence to: David A. Kaminsky, MD, FCCP, Division of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, Given D-213, 89 Beaumont Ave, Burlington, VT 05405; e-mail: david.kaminsky@uvm.edu


For editorial comment see page 568

Funding/Support: This work was supported by the Vermont Lung Center.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;140(3):598-603. doi:10.1378/chest.10-2860
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Background:  The severity of obstructive pulmonary disease is determined by the FEV1 % predicted based on the American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines. In patients with coexisting restrictive lung disease, the decrease in FEV1 can overestimate the degree of obstruction. We hypothesize that adjusting the FEV1 for the decrease in total lung capacity (TLC) results in a more appropriate grading of the severity of obstruction.

Methods:  We examined a large pulmonary function test database and identified patients with both restrictive (TLC < 80% predicted) and obstructive (FEV1/FVC < the lower limit of normal) lung disease. FEV1 % predicted was adjusted for the degree of restriction by dividing it by TLC % predicted. We compared the distribution of severity grading between adjusted and unadjusted values according to ATS/ERS criteria and determined how the distribution of severity would change based on asthma and COPD guidelines.

Results:  We identified 199 patients with coexisting restrictive and obstructive lung disease. By ATS/ERS grading, the unadjusted data categorized 76% of patients as having severe or very severe obstruction and 11% as having mild or moderate obstruction. The adjusted data classified 33% with severe or very severe obstruction and 44% with mild or moderate obstruction. Of the corrected values, 83% resulted in a change to less severe obstruction by ATS/ERS guidelines, and 44% and 70% of patients, respectively, would be reclassified as having less severe obstruction by current asthma and COPD guidelines.

Conclusions:  This method results in a more appropriate distribution of severity of obstruction, which should lead to more accurate treatment of obstruction in these patients.

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