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Advancing Respiratory ResearchAdvancing Respiratory Research

James P. Kiley, PhD
Author and Funding Information

From the Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.

Correspondence to: James P. Kiley, PhD, Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Two Rockledge Centre, 6701 Rockledge Dr, Ste 10042, MSC 7952, Bethesda, MD 20892-7952; email: kileyj@nhlbi.nih.gov


For editorial comment see page 275

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;140(2):497-501. doi:10.1378/chest.11-0774
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Respiratory diseases remain a major public health problem in the United States and worldwide, with increasing morbidity and mortality. Substantial progress has been made to advance understanding of the basic mechanisms of lung disease and to optimize clinical management of patients with a range of respiratory diseases. Despite this progress, our knowledge of how to predict disease prior to symptoms, improve disease definition and subclassification, and target novel and new treatments in a more personalized manner still remains inadequate. This article highlights several future opportunities and challenges related to genomics and molecular characterization of lung disease, lung injury and repair, translational lung research, the microbiome, and sleep and circadian biology as potential frontiers to advance progress in respiratory biology in health and disease.


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