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Original Research: SIGNS AND SYMPTOMS OF CHEST DISEASES |

Do Sex and Atopy Influence Cough Outcome Measurements in Children?Do Sex and Atopy Influence Cough Outcomes?

Anne B. Chang, PhD; Peter G. Gibson, MD; Carol Willis; Helen L. Petsky, BSN; John G. Widdicombe, DPhil, DM; I. Brent Masters, PhD; Colin F. Robertson, MD
Author and Funding Information

From the Queensland Children’s Respiratory Centre and Children’s Medical Research Institute (Drs Chang and Masters and Mss Willis and Petsky), Royal Children’s Hospital, Brisbane, QLD, Australia; Child Health Division (Dr Chang), Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia; Department of Respiratory Medicine (Dr Gibson), John Hunter Hospital, University of Newcastle, NSW, Australia; University of London (Dr Widdicombe), London, England; and Department of Respiratory Medicine (Dr Robertson), Royal Children’s Hospital, Melbourne, Murdoch Children’s Research Institute, University of Melbourne, VIC, Australia.

Correspondence to: Anne B. Chang, PhD, Queensland Children’s Respiratory Centre, Royal Children’s Hospital, Herston, Brisbane, QLD, 4029, Australia; e-mail: annechang@ausdoctors.net


Funding/Support: Drs Chang and Gibson are funded by National Health and Medical Research Council practitioner fellowships [grants 545216 and 569240]. The Royal Children’s Hospital Foundation and Queensland Children’s Medical Research Institute funded Mss Willis and Petsky. Study d cited in this article was funded by the Asthma Foundation of Queensland.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;140(2):324-330. doi:10.1378/chest.10-2507
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Background:  Despite the commonality of cough and its burden, there are no published data on the relationship between atopy or sex on objectively measured cough frequency or subjective cough scores in children. In 202 children with and without cough, we determined the effect of sex and atopy on validated cough outcome measurements (cough receptor sensitivity [CRS], objective cough counts, and cough scores). We hypothesized that in contrast to adult data, sex does not influence cough outcome measures, and atopy is not a determinant of these cough measurements.

Methods:  We combined data from four previous studies. Atopy (skin prick test), the concentration of capsaicin causing two and five or more coughs (C2 and C5, respectively), objectively measured cough frequency, and cough scores were determined and their relationship explored. The children’s (93 girls, 109 boys) mean age was 10.6 years (SD 2.9), and 56% had atopy.

Results:  In multivariate analysis, CRS was influenced by age (C2 coefficient, 5.9; P = .034; C5 coefficient, 29.1; P = .0001). Atopy and sex did not significantly influence any of the cough outcomes (cough counts, C2, C5, cough score) in control subjects and children with cough.

Conclusions:  Atopy does not influence important cough outcome measures in children with and without chronic cough. However, age, but not sex, influences CRS in children. Unlike adult data, sex does not affect objective counts or cough score in children with and without chronic cough. Studies on cough in children should be age matched, but matching for atopic status and sex is less important.

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atopy ; cough

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