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The Early Diagnosis of Pulmonary Arterial HypertensionEarly Diagnosis of Pulmonary Arterial Hypertension: Can We Do Better?

Harold I. Palevsky, MD, FCCP
Author and Funding Information

From the Pulmonary Vascular Disease Program, Pulmonary, Allergy, and Critical Care Division, Penn Presbyterian Medical Center, University of Pennsylvania School of Medicine.

Correspondence to: Harold I. Palevsky, MD, FCCP, Pulmonary Vascular Disease Program, Penn Presbyterian Medical Center, Ste 120, PHI Building, 51 N 39th St, Philadelphia, PA 19104-2699; e-mail: harold.palevsky@uphs.upenn.edu


Financial/nonfinancial disclosures: The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;140(1):4-6. doi:10.1378/chest.11-1149
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In 1981, 32 US medical centers began enrolling patients into the National Institutes of Health-sponsored Patient Registry for the Characterization of Primary Pulmonary Hypertension (NIH-PPH).1 In the ensuing 30 years, considerable progress has been made in understanding the cellular, genetic, and biochemical processes underlying what is now designated pulmonary arterial hypertension (PAH). Clinical trials have led to the availability of multiple therapeutic agents in three pharmacologic classes, with additional agents in these and novel pharmacologic classes under development. Despite this progress in treatment, there remains an unacceptably long delay from the onset of clinical symptoms to diagnosis of PAH, and the majority of patients continue to be in an advanced functional class at the time of diagnosis.

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