In 2010, Streiner and Norman1 reported the discovery of a new disorder, called malignant hypertrophy of the ego (MHE), which is highly prevalent in some groups, such as politicians, actors, academic deans, and neurosurgeons. It may lead to reduced life expectancy for those afflicted with it, with the primary cause of death being murder at the hands of those forced to interact with these people. Imagine a study of the correlates of MHE, in which those with the disorder are compared with a group of control subjects. To begin with, we look for differences between the two groups on a large number of baseline variables, such as age, marital status, education, and so forth—about 20 variables in all. We then administer a series of questionnaires to the two cohorts, looking at such factors as mood, ego strength, personality type, and so on—again, about 20 different variables. We predict a priori that the MHE group will be higher in ego strength and lower in depression than the comparison group, but we do not know what else to expect, especially with regard to how these variables correlate.