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The Natural History and Diagnosis of Idiopathic Pulmonary FibrosisNatural History of Idiopathic Pulmonary Fibrosis: Are We All on the Same Page?

Keith C. Meyer, MD, FCCP
Author and Funding Information

From the Section of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health.

Correspondence to: Keith C. Meyer, MD, FCCP, Section of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, K4/910 CSC, 600 Highland Ave, Madison, WI 53792; e-mail: kcm@medicine.wisc.edu


Financial/nonfinancial disclosures: The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;140(1):3-4. doi:10.1378/chest.11-0401
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Extract

Considerable progress has been made in narrowing the definition of the entity we recognize as idiopathic pulmonary fibrosis (IPF) and in adopting criteria that exclude non-IPF forms of interstitial lung disease (ILD) when a diagnosis of IPF is made.1,2 Nonetheless, IPF remains a somewhat heterogeneous disorder. Many IPF phenotypes have been identified that have a significant impact on disease behavior and patient survival, such as early and relentless clinical deterioration, the development of secondary pulmonary hypertension, abrupt deterioration because of an acute exacerbation of IPF, or IPF with coexistent emphysema. Such disease idiosyncrasies, as well as comorbidities that are detected in many patients, can significantly influence the clinical course of IPF.3

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