As a cardiologist caring for hospitalized patients, I frequently order the placement of peripherally inserted central catheters (PICCs). This approach is safer than using the jugular, subclavian, or femoral vein for venous access, and the procedures for line placement are standardized and routine. Our hospital, like many others, has a nursing team that specializes in the insertion of these indwelling central venous catheters. Their expertise, honed by years of experience and aided by improvements in catheter/needle kit technology, maximizes the likelihood of successful line placement and minimizes the chance of complications such as fluid infiltration into surrounding tissues or catheter infection. PICCs are especially useful for the prolonged infusion of IV amiodarone and pressor agents. And when patients recover from the cardiovascular crisis that required hospitalization, PICCs are vital for hospital discharge planning, to facilitate extended courses of antibiotics such as vancomycin.