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Original Research: ASTHMA |

Hydrogen Peroxide in Exhaled Breath Condensate in Patients with AsthmaPeroxide in Exhaled Breath Condensate in Asthma: A Promising Biomarker?

Yue Teng, MSc; Peili Sun, MD; Jingying Zhang, MSc; Rongbin Yu, PhD; Jianling Bai, PhD; Xin Yao, MD, PhD; Mao Huang, MD, PhD; Ian M. Adcock, PhD; Peter J. Barnes, MD, FCCP
Author and Funding Information

From the Department of Respiratory Medicine (Mss Teng and Zhang and Drs Sun, Yao, and Huang), The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; the Department of Epidemiology and Biostatistics (Drs Yu and Bai), School of Public Health, Nanjing Medical University, Nanjing, China; and the Airway Disease Section (Drs Adcock and Barnes), National Heart and Lung Institute, Imperial College, London, England.

Correspondence to: Xin Yao, MD, PhD, Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029, China; e-mail: yaoxin@njmu.edu.cn


Ms Teng and Dr Sun contributed equally to this work.

Funding/Support: This study was supported by the National Natural Science Foundation of China [Grants 30700342, 81070025], Jiangsu Health Promotion Project, and “the Six Great Talents” [Grant 09-B1-001].

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;140(1):108-116. doi:10.1378/chest.10-2816
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Background:  The measurement of hydrogen peroxide (H2O2) in exhaled breath condensate (EBC) has been proposed as a noninvasive way of monitoring airway inflammation. However, results from individual studies on EBC H2O2 evaluation of asthma are conflicting. The purpose of this study was to explore whether EBC H2O2 is elevated in people with asthma and whether it reflects disease severity and disease control or responds to corticosteroid treatment.

Methods:  Studies were identified by searching PubMed, Embase, Cochrane Database, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and www.controlled-trials.com for relevant reports published before September 2010. Observational studies comparing levels of EBC H2O2 between patients with asthma who were nonsmokers and healthy subjects were included. Data were independently extracted by two investigators and analyzed using Stata 10.0 software.

Results:  Eight studies (involving 728 participants) were included. EBC H2O2 concentrations were significantly higher in patients with asthma who were nonsmokers compared with healthy subjects, and higher values of EBC H2O2 were observed at each level of asthma, classified either by severity or control level, and the values were negatively correlated with FEV1. In addition, EBC H2O2 concentrations were lower in patients with asthma treated with corticosteroids than in patients with asthma not treated with corticosteroids.

Conclusions:  H2O2 might be a promising biomarker for guiding asthma treatment. However, further investigation is needed to establish its role.

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