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Bone Marrow-Derived Stem Cells and Respiratory DiseaseBone Marrow Stem Cells and Respiratory Disease

Carla P. Jones, PhD; Sara M. Rankin, PhD
Author and Funding Information

From the Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, England.

Correspondence to: Sara M. Rankin, PhD, Leukocyte Biology Section, NHLI, Imperial College, Sir Alexander Fleming Bldg, S Kensington Campus, Exhibition Rd, London, SW7 2AZ, England; e-mail: s.rankin@imperial.ac.uk


Funding/Support: Dr Jones is a research associate from the Wellcome Trust (085851/Z/08/Z).

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;140(1):205-211. doi:10.1378/chest.10-2348
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Adult bone marrow contains a number of discrete populations of progenitor cells, including endothelial, mesenchymal, and epithelial progenitor cells and fibrocytes. In the context of a range of diseases, endothelial progenitor cells have been reported to promote angiogenesis, mesenchymal stem cells are potent immunosuppressors but can also contribute directly to tissue regeneration, and fibrocytes have been shown to induce tissue fibrosis. This article provides an overview of the basic biology of these different subsets of progenitor cells, reporting their distinct phenotypes and functional activities. The differences in their secretomes are highlighted, and the relative role of cellular differentiation vs paracrine effects of progenitor cells is considered. The article reviews the literature examining the contribution of progenitor cells to the pathogenesis of respiratory disease, and discusses recent studies using bone marrow progenitor cells as stem cell therapies in the context of pulmonary hypertension, COPD, and asthma.

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