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Original Research: PULMONARY PHYSIOLOGY |

Early and Long-term Validation of an Algorithm Assessing Fitness for Surgery in Patients With Postoperative FEV1 and Diffusing Capacity of the Lung for Carbon Monoxide < 40%

Luis Puente-Maestú, MD, PhD; Felipe Villar, MD; Guillermo González-Casurrán, MD; Nicolás Moreno, MD, PhD; Yolanda Martínez, MD; Carlos Simón, MD, PhD; Rafael Peñalver, MD, PhD; Federico González-Aragoneses, MD, PhD
Author and Funding Information

Servicio de Neumología (Drs Puente-Maestú and Martinez), and Servicio de Cirugía de Tórax (Drs González-Casurrán, Moreno, Simón, Peñalver, and González-Aragoneses), Hospital General Gregorio Marañón Universidad Complutense de Madrid; and Servicio de Neumología (Dr Villar), Fundación Jiménez Díaz, Madrid/CAPIO, CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.

Correspondence to: Luis Puente-Maestú, MD, PhD, Servicio de Neumología, Hospital General Universitario Gregorio Marañón. c/Doctor Esquerdo 46. 28007 Madrid, Spain; e-mail: lpuente.hgugm@salud.madrid.org


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;139(6):1430-1438. doi:10.1378/chest.10-1069
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Background:  There is evidence in the literature that the incidence of pulmonary complications and mortality is fair enough in patients with lower pulmonary function than conventionally accepted. In this article, we validate in patients with low baseline lung function (ie, FEV1 or diffusing capacity of the lung for carbon monoxide [Dlco] < 80%) an algorithm to evaluate anatomic lung surgery in patients with low predicted postoperative lung function (ie, either FEV1-postoperative estimated [ppo] or Dlco-ppo < 40% or both between 30% and 40% predicted) if peak oxygen uptake (Vo2peak)-ppo > 10 mL/kg/min.

Methods:  We prospectively studied 126 consecutive patients evaluated for anatomic resection of lung tumors by thoracotomy.

Results:  Ninety-two patients were operated on: age 67 (8 SD) years; FEV1 63 (14)% pp; Dlco 71 (19)% pp; Vo2peak 71 (19)% predicted; and 2-year Kaplan-Meier conditional probability of survival (CPS) 0.62 (0.06). Thirty-day perioperative mortality was 6.4%. Thirty-four patients were not functionally fit, or rejected the procedure: age 69 (8) years; FEV1 58 (16)% predicted; Dlco 67 (26)% predicted; Vo2peak 66 (16)% predicted. In this group, 2-year CPS was 0.18 (0.08), P < .01. Subgroups A (FEV1-ppo and Dlco-ppo > 40% predicted) and B (either FEV1-ppo or Dlco-ppo < 40% predicted or both between 30% and 40% predicted) were comparable in terms of perioperative morbidity; however, they were different in terms of 30-day mortality (A, 1/53 [1.9%]; B, 5/37 [13.5%]; P = .047; relative risk, 7.2; 95% CI 1.1-27.7). The survival functions of both subgroups were significantly different (P < .01) from nonsurgical subjects.

Conclusions:  Adherence to the proposed algorithm results in a reasonable preoperative mortality in patients with low preoperative lung function. Although perioperative mortality is significantly higher when predicted postoperative lung function is low, 2-year survival of patients is better than if such patients had not undergone surgery.

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