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Effect of Inhaled Corticosteroid Therapy on CT Scan-Estimated Airway Dimensions in a Patient With Chronic Bronchitis Related to Ulcerative Colitis

Satoshi Hamada, MD; Yutaka Ito, MD, PhD; Seiichiro Imai, MD; Tsuyoshi Oguma, MD; Akio Niimi, MD, PhD; Michiaki Mishima, MD, PhD
Author and Funding Information

From the Department of Respiratory Medicine, Kyoto University, Kyoto, Japan.

Correspondence to: Yutaka Ito, MD, PhD, Department of Respiratory Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan; e-mail: yutaka@kuhp.kyoto-u.ac.jp


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;139(4):930-932. doi:10.1378/chest.10-1105
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CT scanning allows assessment of airway-wall thickness and is useful for diagnosing and assessing various lung diseases, including asthma and COPD. Several studies have reported that CT scan-estimated dimensions are positively correlated with pulmonary function test results and a positive response to treatment. However, to our knowledge, airway disease complicated by inflammatory bowel disease has not yet been assessed using CT scan-estimated dimensions. A 61-year-old woman with ulcerative colitis (UC) complained of cough, sputum, and fever 4 months after undergoing a total colectomy and rectal mucosectomy. Examination of bronchial biopsy samples demonstrated lymphocytic and plasma cell infiltration of the epithelium and submucosa. CT scan-estimated dimensions indicated thickening of the airways. Chronic bronchitis complicated with UC was diagnosed, and high-dose inhaled corticosteroid therapy was prescribed. Three months later, the CT scan-estimated dimensions of the patient’s airways, her symptoms, and pulmonary function test results were dramatically improved.

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