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Propylthiouracil-Induced Nonspecific Interstitial Pneumonia

Ji Yeon Lee, MD; Jin-Haeng Chung, MD, PhD; Yeon Joo Lee, MD; Sung Soo Park, MD, FCCP; Seo Yun Kim, MD; Hyeon-kyoung Koo, MD; Jae Ho Lee, MD, PhD; Choon-Taek Lee, MD, PhD; Ho Il Yoon, MD, PhD
Author and Funding Information

From the Division of Pulmonary and Critical Care Medicine (Drs J. Y. Lee, Y. J. Lee, Park, Kim, and Koo), Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul; and the Department of Pathology (Dr Chung), and the Division of Pulmonary and Critical Care Medicine (Drs J. H. Lee, C.-T. Lee, and Yoon), the Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.

Correspondence to: Ho Il Yoon, MD, PhD, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166, Gumi-Ro, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-707, Republic of Korea; e-mail: dextro@snubh.org


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;139(3):687-690. doi:10.1378/chest.10-1558
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Propylthiouracil (PTU) is a drug used to treat hyperthyroidism. A number of adverse effects have been reported with this drug, including fever, agranulocytosis, skin rash, and vasculitis. PTU-induced interstitial pneumonia is rare—only three cases have been reported—and PTU-induced nonspecific interstitial pneumonia (NSIP) has not been reported. We report a patient who developed NSIP after taking PTU for 1 year. She developed dyspnea, cough, and mild fever lasting 1 month, and a chest CT scan showed multifocal patchy consolidation in both lungs. She underwent a surgical lung biopsy, and NSIP was confirmed pathologically. The symptoms and abnormalities seen in the chest radiograph improved after withdrawal of PTU. To our knowledge, this is the first documented case of pathologically proven PTU-induced NSIP.

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