0
Original Research: DIFFUSE LUNG DISEASE |

Depression and Functional Status Are Strongly Associated With Dyspnea in Interstitial Lung Disease

Christopher J. Ryerson, MD; Jane Berkeley, BA; Virginia L. Carrieri-Kohlman, RN, DNSc; Steven Z. Pantilat, MD; C. Seth Landefeld, MD; Harold R. Collard, MD, FCCP
Author and Funding Information

From the Department of Medicine (Drs Ryerson, Pantilat, Landefeld, and Collard and Ms Berkeley), School of Medicine, and Department of Physiological Nursing (Dr Carrieri-Kohlman), School of Nursing, University of California San Francisco, San Francisco, CA.

Correspondence to: Harold R. Collard, MD, FCCP, 505 Parnassus Ave, Box 0111, San Francisco, CA 94143; e-mail: hal.collard@ucsf.edu


Funding/Support: This study was supported by the Association of Specialty Professors/CHEST Foundation Geriatric Development Research Award.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2011 American College of Chest Physicians


Chest. 2011;139(3):609-616. doi:10.1378/chest.10-0608
Text Size: A A A
Published online

Background:  Little is understood about the characteristics of dyspnea in patients with interstitial lung disease (ILD), and its severity is likely influenced by multiple factors. Depression and functional status are known to influence dyspnea in patients with COPD. The aim of this study was to determine the relationship of dyspnea with clinical parameters, including depression and functional status, in patients with ILD.

Methods:  Dyspnea was measured with the Baseline Dyspnea Index and the University of California San Diego Shortness of Breath Questionnaire. Clinical parameters were recorded. Regression analysis was performed to determine independent correlates of dyspnea.

Results:  Fifty-two subjects were enrolled. The two dyspnea scales were strongly correlated (r = −0.79; P < .00005). The mean levels of dyspnea were 6.5 and 41.0, representing a moderate degree of dyspnea. Clinically meaningful depressive symptoms were found in 23% of subjects. Independent correlates of dyspnea severity for each dyspnea scale were depression score (P = .002 and P < .0005), 4-m walk time (P = .001 and P = .06), FVC (P = .07 and P = .004), and diffusing capacity of the lung for carbon monoxide (P = .007). BMI had borderline significant association with the Baseline Dyspnea Index (P = .10).

Conclusions:  In patients with ILD, dyspnea is associated with depression score, functional status, and pulmonary function. These results suggest that attention to depression and functional status is important in these patients and that treatment directed at these comorbidities may improve dyspnea and quality of life.

Trial registry:  ClinicalTrials.gov; No.: NCT00611182 ; URL: www. clinicaltrials.gov

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543