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Recent Advances in Chest Medicine |

Recent Advances in Testing for Latent TB

Neil W. Schluger, MD; Joseph Burzynski, MD, MPH
Author and Funding Information

From the Division of Pulmonary, Allergy, and Critical Care Medicine and the Department of Medicine, College of Physicians and Surgeons (Drs Schluger and Burzynski), and the Departments of Epidemiology and Environmental Health Sciences, Mailman School of Public Health (Dr Schluger), Columbia University; and the Tuberculosis Control Program (Dr Burzynski), New York City Department of Health and Mental Hygiene, New York, NY.

Correspondence to: Neil W. Schluger, MD, Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, 622 W 168th St, New York, NY 10032; e-mail: ns311@columbia.edu


Funding/Support: This study was funded by the National Heart, Lung and Blood Institute/National Institutes of Health [Grant K24 HL004074].

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;138(6):1456-1463. doi:10.1378/chest.10-0366
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After more than a century of relying on skin testing for the diagnosis of latent TB infection, clinicians now have access to blood-based diagnostics in the form of interferon γ release assays (IGRAs). These tests are generally associated with higher sensitivity and specificity for diagnosis of latent TB infection. This article reviews the indications for testing and treatment of latent TB infection in the overall context of a TB control program and describes how IGRAs might be used in specific clinical settings and populations, including people having close contact with an active case of TB, the foreign born, and health-care workers.

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