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Original Research: INHERITED LUNG DISEASES |

Predictors of Influenza Vaccination in the Cystic Fibrosis Foundation Patient Registry, 2006 Through 2007

Justin R. Ortiz, MD; Kathleen M. Neuzil, MD; John C. Victor, PhD; Moira L. Aitken, MD, FCCP; Christopher H. Goss, MD, FCCP
Author and Funding Information

From the Division of Pulmonary and Critical Care Medicine (Drs Ortiz, Goss, and Aitken) and Division of Allergy and Infectious Diseases (Dr Neuzil), Department of Medicine, University of Washington, Seattle, WA; and PATH (Drs Neuzil and Victor), Seattle, WA.

Correspondence to: Justin R. Ortiz, MD, Division of Pulmonary and Critical Care Medicine, University of Washington Medical Center, Box 356522, 1959 NE Pacific St, Seattle, WA 98195-6522; e-mail: jrortiz@u.washington.edu


A prior version of this study was presented in poster form (Ortiz JR, Aitken ML, Goss CH. Influenza Vaccination Coverage in Cystic Fibrosis Exceeds United States Government Goals. Am J Respir Crit Care Med. 2009;179:A1441).

Funding/Sponsor: This research was supported in part by a National Heart, Lung, and Blood Institute respiratory research training grant [HL007287] (to Dr Ortiz) and by the Cystic Fibrosis Foundation [GOSS00L0] (to Dr Goss).

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;138(6):1448-1455. doi:10.1378/chest.10-0356
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Background:  Influenza vaccination is recommended for all persons with cystic fibrosis (CF). Despite this recommendation, no study has been performed to determine factors associated with receipt of influenza vaccination among persons with CF.

Methods:  We conducted a 2-year cohort study from 2006 through 2007 using the CF Foundation (CFF) Patient Registry to assess predictors of influenza vaccination with logistical regression modeling.

Results:  In 2006, the cohort consisted of 16,435 persons with vaccination data seen at CFF care centers. Vaccination rates were high for children aged < 5 years (90.5%), children 5 to < 18 years (91.1%), and adults (87.9%). In 2006, decreased odds of vaccination were seen among adults with other or unknown insurance (0.37; 95% CI, 0.15-0.87). Among children 5 to < 18 years and adults, decreased odds of vaccination were seen among Hispanics (children, 0.74; 95% CI, 0.55-0.98; adults, 0.67; 95% CI, 0.46-0.98) and with use of oxygen therapy (children, 0.55; 95% CI, 0.38-0.78; adults, 0.68; 95% CI, 0.55-0.86), whereas four or more clinic visits annually was associated with increased odds of vaccination (children, 2.33; 95% CI, 1.92-2.84; adults, 2.05; 95% CI, 1.71-2.47). Findings associated with decreased vaccine receipt remained significant in sensitivity analyses that assumed missing vaccination data were vaccine positive.

Conclusions:  Overall influenza vaccination rates are very high in the US CF population. Knowledge of influenza vaccination predictors among persons with CF may aid clinicians in targeting patients at greater risk for influenza infection. These data may have important implications for the evolving pandemic 2009 influenza A(H1N1).


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