Poster Presentations: Wednesday, November 3, 2010 |

Functional Involvement in a Cohort of Patients With Rheumatoid Arthritis FREE TO VIEW

Gabriela C. Tabaj, MD; Valentina Di Boscio, MD; Luciana Molinari, MD; Renzo Villagomez, MD; Silvia Quadrelli, MD
Author and Funding Information

Hospital Britanico and Hospital Cetrangolo, Capital Federal, Argentina

Chest. 2010;138(4_MeetingAbstracts):537A. doi:10.1378/chest.10933
Text Size: A A A
Published online


PURPOSE: To describe the characteristics of the pulmonary function tests (PFTs) in a cohort of patients with diagnosis of rheumatoid arthritis (RA).

METHODS: we prospectively evaluated, with forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), total lung capacity (TLC), residual volume (RV) and diffusing capacity for carbon monoxide (DLCO) a cohort of 36 patients with diagnosis of RA. The results were expressed in absolute values and as percentages of predicted values.

RESULTS: we include 36 consecutive patients with RA (25 females and 11 males, mean age: 56±11.2 years). The mean values were for FVC 2.7 l ± 0.76 (82% ± 19), FEV1 2.2 l ± 0.61 (91% ± 22) and for FEV1 /FVC 82 ±4.6, for lung volumes were: total lung capacity (TLC) 4.7 l ± 0.8 (93 % ± 35.5), functional residual capacity (FRC) 0.5 l ± 0.18 (48% ± 13), residual volume (RV) 1.06 ± 0.4, VER 45± 44.7 and RV/TLC 42± 9.9. The mean diffusing capacity for carbon monoxide (DLCO) measured by single breath expressed in percentage was 69.7% ± 28, adjusted by hemoglobin 71.9% ± 31 and the kCO (DLCO/AV) 99% ± 19.The 38.8% of the patients showed a decrease in the FVC (< 80%), and of these, only 35% manifested dyspnea. Only in one patient (2.7%) we founded airway obstruction measured by the spirometry and in no case we evidenced hyperinsuflaction (TLC<120%), 63.8% showed DLCO < 80% and only 9 (39%) refered dyspnea and 11 (47%), declined of FVC. Of the total of 17 patients without dyspnea, 8 had abnormal DLCO (47%).

CONCLUSION: Obstructive and restrictive defects in the spirometry and a decrease of the DLCO are frequently seen in patients with RA, even in asymptomatic patients.

CLINICAL IMPLICATIONS: Nearly 50% of the patients with RA present extra-articular manifestations. Although cardiovascular disease is responsible for the majority of RA-related deaths, pulmonary complications can cause 10-20% of overall mortality.Functionally, are described restrictive and obstructive ventilatory defects, the lasts, related with airway involvement.

DISCLOSURE: Gabriela Tabaj, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543