PURPOSE: Several trials have demonstrated increased incidence and prevalence of Hypertension(HTN) in patients with Obstructive Sleep Apnea(OSA). Studies also demonstrate relationship between obesity and sleep apnea. However, long-term effect of treatment of OSA on blood pressure and body mass index(BMI) is lacking. We studied the long term effect of treatment of sleep apnea on systolic BP(SBP), diastolic BP(DBP) and BMI in VA clinical population.
METHODS: Electronic medical records were reviewed for new entries of Obstructive Sleep apnea(OSA) diagnosis between October 2008 and December 2008. For patients who were started on treatment for OSA, we recorded BMI, Systolic Blood Pressure(SBP) and Diastolic Blood Pressure(DBP) at 0-3 months before treatment and 9-12 months after treatment prescription.
RESULTS: 157 charts were reviewed. 92 (58.5%) patients were excluded: 73 (46.4%) patients had no diagnostic work-up and/or treatment. 19 treated patients had no BMI and Blood Pressure(BP) in the specified period. The analysis group included 65 patients. All patients(100%) were men. Age range was 58 11 years. There was no difference between BMI, SBP or DBP at baseline and 1 year (34.81 and 34.86, 130.5 and 128.76, 78.93 and 77.46 respectively). 16 patients had objective compliance data. 8 patients demonstrated good compliance (usage >70% of nights, average usage >4hrs per night). There was no significant change in BMI, SBP or DBP in this group. 14 patients had elevated BP (SBP>140mm Hg or diastolic BP>90 mm Hg) at baseline. There was a significant change in SBP (147.4 to 136.1, p<.03) but not in DBP (84.7 to 80.46, p=0.26).
CONCLUSION: Treatment of OSA resulted in signifcant decrease in systolic blood pressure at 1 year in patients with elevated baseline blood pressure.There was no impact on Body Mass Index at 1 year.
CLINICAL IMPLICATIONS: In the VA population, treatment of Obstructive sleep apnea assists in management of uncontrolled Hypertension.
DISCLOSURE: Mohammed Moizuddin, No Financial Disclosure Information; No Product/Research Disclosure Information