Poster Presentations: Wednesday, November 3, 2010 |

Particularities of Sleep Apnea Syndrome in Patients With Acromegaly in a Sleep Population From Timisoara, Romania FREE TO VIEW

Stefan D. Mihaicuta, MD; Daniela Amzar, MD; Carmen Ardelean, MD; Stefan Frent, MD; Voicu Tudorache, MD
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University of Medicine and Pharmacy V Babes, Timisoara, Romania

Chest. 2010;138(4_MeetingAbstracts):633A. doi:10.1378/chest.10874
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PURPOSE: Sleep apnea syndrome (SAS) is considered a common disorder in acromegaly To evaluate particularities of factors for sleep apnea syndrome (SAS) among patients with acromegaly.

METHODS: We evaluated 13 patients with acromegaly from 957 consecutive patients to be evaluated for sleep apnea syndrome in the interval June 2005- June 2009. We divided patients (n=13) into 2 groups according to AHI and we evaluated: age, gender, BMI, smoking, neck and abdominal circumference, medical history, symptoms, Epworth scale, polysomnography for sleep studies (apnea-hypopnea index AHI, oxyhaemoglobin saturation, heart rate).

RESULTS: In group with AHI< 10 were 3 patient, all females, mean age 47 ± 7 years (range 43-59), mean BMI 30±1,2 kg/m2, one of 3 smoker, mean neck circumference 39.3 ± 2,1cm, mean abdominal circumference 93.3± 5,6 cm, hypertension 2 of 3. Symptoms: all reported recurent awaking from sleep, apnea reported by other, morning headache and nocturia (2 of 3), loud snoring and restless sleep (1 of 3), none reported excessive daytime sleepiness. Mean Epworth scale 5.33±2,1, mean AHI=5.66±2,1, mean heart rate 80.3± 4,7 beats/min, lowest desaturation 91.6%±2,1.In group with AHI>10 were 10 patients, 7 females and 3 males, mean age 48.3 ± 12 (31-62), 3 of 10 smokers, BMI 35.7 ± 5.57 kg/m2, neck circumference 40.8 ± 3.79 cm, abdominal circumference 107.4 ± 9.98 cm, hypertension 50 %. Symptoms: recurent awaking from sleep (90%), loud snoring, morning headache, restless sleep and nocturia (6 of 10), apnea reported by other and excessive daytime sleepiness (5 of 10). Mean Epworth scale 9 ± 5.72 (2-20). Mean AHI 34 ± 17 (17-68), heart rate 73.1% ± 7.71%, lowest desaturation 82.69 ± 11.7 % (96-51), desaturation index 15 ± 11.8 (5-45).

CONCLUSION: The prevalence of SAS in acromegaly is high, similar to other series. AHI was correlated significantly with gender (female), abdominal circumference, BMI, Epworth scale, symptoms (excessive daytime sleepiness, loud snoring and restless sleep), lowest desaturation, desaturation index.

CLINICAL IMPLICATIONS: Sleep apnea syndrom is common in acromegaly. Sleep study is mandatory.

DISCLOSURE: Stefan Mihaicuta, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




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