PURPOSE: To know the prevalence of drug resistance among treatment failure cases in different regimens of Tuberculosis ,which is important for further management and control of tuberculosis.
METHODS: Drug sensetivity was carried on 108 Mycobacterial isolates using critical concentration in Lowenstein Jenson medium.
RESULTS: In Dots cat.I failure 55%were resistant to Isoniazid ,45%to rifampcin,15%to streptomycin, while in Dots Cat II 78.2%resistant to INH,60.8 to RMP, 26%toSM.In Cat III 26.6% resistant to INH ,13.3% to RMP,^.6% to EMB.Resistant to INH&RMP in Dots Cat I were 45%,60.8% in Cat II,13.3% in Cat III. Resistance to three drugs were 20% in Dots CatI ,8.6% in catII.
CONCLUSION: Significantly high drug resistance were present in DOTS CatI & catII failure cases of Tuberculosis .
CLINICAL IMPLICATIONS: Close monitoring is required in DOTS CatI & CatII patients of Tuberculosis to identify failures early and if necessary change of treatment who do not show early response to treatment.
DISCLOSURE: Rakesh Bhargava, No Financial Disclosure Information; No Product/Research Disclosure Information