Poster Presentations: Wednesday, November 3, 2010 |

Drug Resistance Pattern in Treatment Failure Cases of Tuberculosis (Cat I, Cat II, Cat III) FREE TO VIEW

Rakesh Bhargava, MD; Zuber Ahmad, MD; Jamal Akhtar, MBBS
Author and Funding Information

J.N.Medical College, Aligarh, India

Chest. 2010;138(4_MeetingAbstracts):677A. doi:10.1378/chest.10837
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PURPOSE: To know the prevalence of drug resistance among treatment failure cases in different regimens of Tuberculosis ,which is important for further management and control of tuberculosis.

METHODS: Drug sensetivity was carried on 108 Mycobacterial isolates using critical concentration in Lowenstein Jenson medium.

RESULTS: In Dots cat.I failure 55%were resistant to Isoniazid ,45%to rifampcin,15%to streptomycin, while in Dots Cat II 78.2%resistant to INH,60.8 to RMP, 26%toSM.In Cat III 26.6% resistant to INH ,13.3% to RMP,^.6% to EMB.Resistant to INH&RMP in Dots Cat I were 45%,60.8% in Cat II,13.3% in Cat III. Resistance to three drugs were 20% in Dots CatI ,8.6% in catII.

CONCLUSION: Significantly high drug resistance were present in DOTS CatI & catII failure cases of Tuberculosis .

CLINICAL IMPLICATIONS: Close monitoring is required in DOTS CatI & CatII patients of Tuberculosis to identify failures early and if necessary change of treatment who do not show early response to treatment.

DISCLOSURE: Rakesh Bhargava, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




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