Poster Presentations: Tuesday, November 2, 2010 |

The Effect of siRNA-Ku70 on the Expression of Apoptosis-Related Genes in A549DDP FREE TO VIEW

Jie Zhang, PhD; Ke Wang, PhD
Author and Funding Information

2nd hospital of Jilin University, Changchun, Peoples Rep of China

Chest. 2010;138(4_MeetingAbstracts):264A. doi:10.1378/chest.10807
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PURPOSE: To investigate the effect of SiRNA-Ku70 in drug-resistance in A549DDP cell line.

METHODS: Expression of apoptosis-related genes was examined by PCR-Array assay.

RESULTS: Expression of BAX,P53 and P73 increased significantly whereas the expression of TRAF and BFAR decreased in SiRNA-Ku70 A549DDP cells compared to A549DDP cells (P< 0.05) .

CONCLUSION: These results show that Ku70 might play an important role in drug-resistance in A549DDP cell line. Silencing of Ku70 can be attributed to the elevation of apoptotic genes- BAX, P53 and P73 expression; reduction of anti-apoptotic genes TRAF and BFAR. This study suggests that silencing of Ku70 might reverse the drug-resistance in A549DDP cell line.

CLINICAL IMPLICATIONS: Ku70 might be a new target for the drug-resistant reversion.

DISCLOSURE: Jie Zhang, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




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