Poster Presentations: Wednesday, November 3, 2010 |

Immediate Effects of Environmental Tobacco Smoke on Exhaled Nitric Oxide and Lung Mechanics in Passive Smokers FREE TO VIEW

Nektarios Anagnostopoulos, MD; Marios S. Kougias, MD; Constantine I. Vardavas, PhD; Irene Avlonitou, MD; Vassiliki Evangelopoulou, MD; Miltos Vassiliou, MD; Panagiotis K. Behrakis, MD
Author and Funding Information

Hellenic Cancer Society, Center of Smoking Research, Donation of G.D. Behrakis, Athens, Greece

Chest. 2010;138(4_MeetingAbstracts):577A. doi:10.1378/chest.10783
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PURPOSE: The exposure to Environmental Tobacco Smoke (ETS) has been extensively studied as a factor influencing respiratory mechanics and airway inflammatory markers. Most of these studies refer to rather chronic and midterm exposure to ETS. The aim of the present study was to provide systematic data of the immediate effects of ETS on respiratory mechanics and Exhaled Nitric Oxide (FeNO) in non-smokers.

METHODS: Fifteen non-smoker volunteers (nine women and six men) of mean age 33 ±13 (years ± Standard Deviation), were studied. Exhaled Nitric Oxide (FeNO) [chemiluminescence analyzer (Ecomedics CLD 88sp)] and Impulse Oscillometry (IOS) at 5, 10 and 20 Hz [Viasys Masterscreen System] measurements were performed before and immediately after a 20 minutes exposure to ETS conditions, constantly monitored at 5 mg per cubic meter (TSI Sidepak AM510 particle monitor, with a cut-off aerodynamic diameter of 2,5 microns). A non parametric sign test for paired values was used for statistical analysis.

RESULTS: ** FeNO (ppb) was decreased by 27,31% from 15,34 ± 1,38 to 11,15 ± 1,21 (p<0,001). Impedance Z at 5 Hz [kPa/(L/s)] was increased by 30,55% from 0,36 ± 0,03 to 0,47 ± 0,05 (p=0,003). Peripheral resistance (Rp)[kPa/(L/s)] was increased by 38,10% from 0,21 ± 0,04 to 0,29 ± 0,06 (p=0,038). Cenral Resistance (Rc)[kPa/( L/s)] was increased by 22,22% from 0,18 ± 0,03 to 0,22 ± 0,03 (p=0,047). Resistance (R) measurements at 5, 10 and 20 Hz were also significantly increased (p<0,008). Reactance (X) and Resonant Frequency (RF) results were inconclusive. **Results are expressed as mean ± Standard Error.

CONCLUSION: Exposure to ETS, for a short period of time, decreases FeNO and increases airway impedance and resistance, at frequencies of 5, 10 and 20 Hz.

CLINICAL IMPLICATIONS: Even the short exposure to ETS has serious and immediate effects on lung mechanics and inflammatory status of the respiratory system.

DISCLOSURE: MARIOS KOUGIAS, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




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