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Slide Presentations: Wednesday, November 3, 2010 |

Immediate Effects of Smoking of a Single Cigarette on Exhaled Nitric Oxide and Lung Mechanics in Young Adults FREE TO VIEW

Marios S. Kougias, MD; Nektarios Anagnostopoulos, MD; Constantine I. Vardavas, PhD; Andriani Loukopoulou, BSc; Vassiliki Evangelopoulou, MD; Miltos Vassiliou, MD; Panagiotis K. Behrakis, MD
Author and Funding Information

Hellenic Cancer Society , Center of Smoking Research ,Donation of G.D. Behrakis, Athens, Greece



Chest. 2010;138(4_MeetingAbstracts):919A. doi:10.1378/chest.10769
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Abstract

PURPOSE: Chronic effects of smoking on lung inflammatory processes and respiratory mechanics have been thoroughly studied. However, the immediate effects of smoking, in young adults, have not been extensively examined. The aim of the present study is to provide systematic data of the immediate effects of a single cigarette smoking on the respiratory system of young adults.

METHODS: Thirty two (32) young healthy volunteers (fifteen male and seventeen female) of mean age 23 ± 1,92 (years ± Standard Deviation) with a smoking history of less than 8 packyears, were studied. Exhaled Nitric Oxide (FeNO) [chemiluminescence analyzer (Ecomedics CLD 88sp)] and Impulse Oscillometry (IOS) at 5, 10 and 20 Hz [Viasys Masterscreen System] measurements were performed before and immediately after smoking of a single cigarette of their usual brand. Results obtained on FeNO, Impedance (Z), central and peripheral resistance (Rc,Rp), Reactance (X), Resonant Frequency (RF) were analyzed ,using the non parametric sign test for paired values.

RESULTS: ** FeNO (ppb) was decreased by 17,11% from 11,98 ± 0,90 to 9,93 ± 0,72 (p<0,001). Impedance(Z) at 5 Hz [kPa/(L/s)] was increased by 7,50% from 0,40 ± 0,02 to 0,43 ± 0,02 (p=0,003). Peripheral Resistance (Rp)[kPa/(L/s)] was increased by 12,50 % from 0,24 ± 0,02 to 0,27 ± 0,02 (p=0,035). Total Resistance R [kPa/(L/s)] at 5 Hz was increased by 5,13% from 0,39 ± 0,02 to 0,41 ± 0,02 (p=0,008). Total Resistance at 10 and 20 Hz, Central Resistance (Rc),Reactance (X) and Resonant Frequency (RF) results were inconclusive. ** Results are expressed as mean ± Standard Error.

CONCLUSION: Smoking of a single cigarette decreases FeNO and increases airway impedance and resistance in young adults.

CLINICAL IMPLICATIONS: Even the consumption of a single cigarette affects lung mechanics and inflammatory status of the respiratory system of young adults.

DISCLOSURE: MARIOS KOUGIAS, No Financial Disclosure Information; No Product/Research Disclosure Information

2:15 PM - 3:45 PM


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