Poster Presentations: Tuesday, November 2, 2010 |

DCAMLK-1 Expression in Lung Cancer FREE TO VIEW

Mazen Zouwayhed, MD; Jijo John, MD; Randal J. May, MD; Stan A. Lightfoot, MD; Courtney W. Houchen, MD; Gary T. Kinasewitz, MD
Author and Funding Information

Oklahoma University Health Science Center/ VA Medical Center, Oklahoma City, OK

Chest. 2010;138(4_MeetingAbstracts):245A. doi:10.1378/chest.10545
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PURPOSE: DCAMLK-1, a marker of colonic crypt stem cells, is a Ca++-calmodulin dependent protein kinase that is highly expressed in most colorectal carcinomas. Even though, the lung develops from the embryological foregut, DCAMLK-1 is not expressed in normal respiratory epithelium. We hypothesized that DCAMLK-1 would also be upregulated in lung cancers.

METHODS: After IRB approval, informed consent was obtained from prospectively identified patients undergoing diagnostic bronchoscopy for suspected lung cancer at the Oklahoma City VA Medical Center. DCAMLK-1 message expression was determined in cells obtained by BAL while protein levels were determined by the immunoreactivity of biopsy specimens.

RESULTS: Six males (age 57-80 years, all smokers, FEV1/FVC ratio 55-61%) were ultimately diagnosed with non-small cell carcinoma (n=3) or benign disease (n=3). DCAMLK-1 message expression was detected in BAL from all subjects. Weak (1+) DCAMLK-1 protein expression was observed in those without cancer, whereas markedly increased (4+) DCAMLK-1 protein expression was noted in the biopsies from the patients with endobronchial malignancy.

CONCLUSION: DCAMLK-1 message is upregulated in the lungs of smokers with COPD, and DCAMLK-1 is highly expressed in the cancers of patients with non-small cell lung carcinoma.

CLINICAL IMPLICATIONS: Upregulation of DCAMLK-1 in the lungs of smokers may contribute to the subsequent development of lung cancer.

DISCLOSURE: Mazen Zouwayhed, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




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