PURPOSE: To analyze correlation between apnea-hipopnea index (AHI), maximal nocturnal desaturation (MND), percent of predicted FEV1, diurnal oxigen saturation (SaO2), smoking, body mass index (BMI) and age at patients with OS from 2 sleep labs from Romania: M. Nasta Bucharest and V. Babes Timisoara.
METHODS: 74 consecutive patients (November 2003 - January 2009) with OSA (AHI>5/h and FEV1/FVC< 70%), men, with smoking history were evaluated with sleep questionnaires, anthropometric measurements, spirometry for FEV1 and FEV1/VC, poligraphy and polisomnography for apnea-hypopnea index (AHI normal 0-4, mild 5-14, moderate 15-29, severe >30) and maximal nocturnal desaturation (MND). We measured correlations between variables for entire population and for subgrups (AHI=15-29/h and AHI>30/h, active and former smokers) with histograms, non-linear simple and multiple correlations, Pearson χ2 and t test(ANOVA).
RESULTS: 4/74 mild OSA, 16/74 moderate OSA, 50/74 severe OSA; 45/74 active smokers, 39/74 former smokers.Mean for 74 OS: age 54.7+/-8.8 yrs, FEV1 55+/-21%, AHI 51+/-28/h, SaO2 89.8+/-16.6%, MND 70+/-16%, BMI 35.7+/-7kg/m2, PY 39.5+/-21. There are significant correlations for 74 OS (p< 0.05, χ2test) between SaO2-MAD and SaO2-BMI. There is no correlation for moderate OSA. For severe patients are correlations between FEV1%-SaO2, MND-SaO2 and MND-AHI. Significant differences (p< 0.05, t test) between active (45/74) and former smokers (29/74) was found regarding mean age CI 95% [0.4-8.7], mean FEV1% CI 95% [-4.3-15.5] and mean AHI CI 95% [2-27].
CONCLUSION: Correlations between variables defining severity of diseases (expressed by AHI and MND for OSA and by FEV1 and SaO2 for COPD) are more powerful with severity degree of OSA (more correlations in patients with AHI>30/h). Active smoking is correlated with a higher severity of OS.
CLINICAL IMPLICATIONS: OSA and COPD are two common diseases that coexists in 0,5-1% of the population, with increased prevalence and awareness.
DISCLOSURE: Stefan Mihaicuta, No Financial Disclosure Information; No Product/Research Disclosure Information