Poster Presentations: Wednesday, November 3, 2010 |

Varicella Zoster Virus Pneumonia in Adults FREE TO VIEW

Victoria Smith-Ferres, PhD; Isabel Betlloch, PhD; Jaime Signes-Costa, PhD; Eusebi Chiner, PhD; Estrella Fernandez-Fabrellas, PhD; Rafael Blanquer, PhD; Jose Blanquer, PhD
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Neumologia. Hospital San Juan de Alicante, Alicante, Spain

Chest. 2010;138(4_MeetingAbstracts):601A. doi:10.1378/chest.10323
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PURPOSE: The objective of this study was to analyze the epidemiological, clinical, radiographic and prognostic characteristics in a large simple of patients with VZV pneumonia in a Spanish region (Valencia, Spain).

METHODS: A 10-year retrospective, descriptive, observational study was carry out in several hospitals. We studied 46 patients with VZV pneumonia, 21 men and 25 women, with a mean age 36±11 years, and 35 were smokers (76%).

RESULTS: The symptoms were: fever (83%), cough (83%), dyspnea (63%), pleuritic pain (70%), and hemoptysis (6%). Onset of blisters preceded chest problems in 3-5 days, but in 5 patients (11%) respiratory symptoms appeared first. A contact with an index case was observed in 57% of patients. Arterial blood gases showed a mean PO2/FiO2 of 308±101 and 30 patients had a PO2 lower than 55 mmHg. In this group of patients with acute respiratory failure, 11 were admitted to the ICU and 8 required mechanical ventilation. Comparison of patients in ICU with those on general wards showed differences in the duration of fever (6.1±4.2 vs 3.2±1.1 days, p< 0.001), mean stay (16.8±9.3 vs 7.2±2.4 days, p< 0.001), and presence of acute renal failure (p=0.01) and acute respiratory failure (p< 0.001). There were no deaths in the whole group. Treatments included acyclovir (98%) combined with steroids in 6 patients and with antibiotics in 3 (complicated with bacterial pneumonia). The prevalence was 0.33/100,000 inhabitants/year.

CONCLUSION: We conclude that VZV pneumonia may have a severe course, with 23% of ICU admissions. Smoking was a risk factor for VZV pneumonia.

CLINICAL IMPLICATIONS: Absence of mortality may be related to early treatment with acyclovir.

DISCLOSURE: Jaime Signes-Costa, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




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