PURPOSE: To determine until when does Glutarldehyde Blood Coagulation Test (GBCT) be positive in children who are under treatment for tuberculosis.
METHODS: This is a prospective, descriptive study of children, ages 2 -14 years old diagnosed to have Tuberculosis Disease. The EDTA containing serum of these children were mixed with equal amounts of 2.5% gutaraldehyde. A positive GBCT reaction was recorded as coagulation, gel formation within 10 minutes. Those who had positive GBCT upon diagnosis were followed up on the 2nd week, then monthly thereafter. GBCT was done on each visit until they completed 6 months of antituberculosis therapy.
RESULTS: 14 patients were included in the study. A negative GBCT was obtained in one (7%) on the second month, three (21%) on the 3rd month, and six (43%) on the 5th and 6th month. No patient converted back to positive once they tested negative for GBCT. The average number of months of obtaining a positive GBCT was 4. 56 months.
CONCLUSION: The Glutaraldehyde Blood Coagulation Test still remains positive in fifty seven percent (57%) of subjects in sixth month while under treatment for Tuberculosis Disease. The average months to be positive was 4.56 months.
CLINICAL IMPLICATIONS: Glutaraldehyde Blood Coagulation Test can be used as an adjunct for the diagnosis of tuberculosis in children. However, its value as monitoring of the disease progression is yet to be verified.
DISCLOSURE: Sonia Ulanday, No Financial Disclosure Information; No Product/Research Disclosure Information