PURPOSE: Objective To evaluate pulmonary function in patients suffered from diabetes mellitus(DM) and to identify whether the lung is one of the target organs of chronic pathologic changes in DM.
METHODS: Pulmonary function of 298 patients with DM and 300 healthy subjects were investigated retrospectively. VC, FVC. FEV1, FEV1/FVC and MVV were used as the indicator of ventilation function; DLCO was used as the indicator of diffusion capacity of lung. The relationship between DM’s durations and lung function changes was analyzed and also the relationship between DM combined with blood pressure and lung function.
RESULTS: Results Pulmonary ventilation function reduced in patients with DM compared to the control group without significant differences (P>0.05). Ventilation function indicators of the DM group were as followed: VC=92.2±17.3%, FVC=2.6±0.8L,FEV1=90.0±17.1%,FEV1/FVC=78.2±6.9%, MVV=82.0±19.5%. Ventilation function indicators of the control group were as followed: VC=99.9±15.7%, FVC=3.0±0.7 L, FEV1=98.4±15.6%, FEV1/FVC=78.3±4.0%, MVV=91.2±17.1%.Although pulmonary diffusion capacity in patients with DM was in the normal range (91.4±16.7%), it was significantly lower than that in the control group(P<0.001). There was no relationship between DM’s durations and pulmonary diffusion capacity changes (F = 0.439, P = 0.508). Pulmonary diffusion capacity in DM patients with hypertension was lower than that with normal blood pressure without significant difference (P>0.05). Pulmonary diffusion capacity was lower in patients with higher blood pressure, but there were no significant differences (P>0.05).
CONCLUSION: Conclusion Impaired pulmonary function, especially diffusion capacity, was manifest in patients with DM. Lung is one of the target organs of chronic pathologic changes in DM.
CLINICAL IMPLICATIONS: This indicated that the patients suffered with diabetes should be managed lung function.
DISCLOSURE: Guifang Wang, No Financial Disclosure Information; No Product/Research Disclosure Information